F is for Fluoroquinolone

May 12, 2021

Fluoroquinolones are an antibiotic that increase the risk for tendinopathy and achilles tendon ruptures.

Ciprofloxacin antibiotic drug (fluoroquinolone class), chemical structure

Fluoroquinolones are a class of antibiotics that are used to treat various bacterial infections. They are effective against a wide range of bacteria, including both gram-negative and gram-positive bacteria. Fluoroquinolones work by inhibiting the activity of enzymes called DNA gyrase and topoisomerase IV, which are necessary for bacterial DNA replication and repair. This disruption in bacterial DNA processes leads to the inhibition of bacterial growth and ultimately helps in eradicating the infection.

Fluoroquinolones are commonly prescribed:

  1. Urinary Tract Infections (UTIs): Fluoroquinolones are frequently used to treat uncomplicated and complicated urinary tract infections caused by susceptible bacteria.
  2. Respiratory Tract Infections: They are used for the treatment of respiratory infections such as bronchitis, pneumonia, and sinusitis caused by susceptible bacteria.
  3. Skin and Soft Tissue Infections: Fluoroquinolones can be prescribed for the treatment of skin and soft tissue infections caused by susceptible bacteria, including cellulitis, abscesses, and wound infections.
  4. Bone and Joint Infections: In some cases, fluoroquinolones may be used to treat bone and joint infections caused by susceptible bacteria.
  5. Gastrointestinal Infections: They may be prescribed for certain gastrointestinal infections, including infectious diarrhea and intra-abdominal infections caused by susceptible bacteria.


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